The Arkansas Rural Health Partnership, Inc. (ARHP) RROE project covered 11 rural counties in Southeast Arkansas, known as the Arkansas Delta, with a total population of 244,978 residents. Nine of these counties were designated as medically underserved areas. ARHP used RROE funding to do a deep dive into data on emergency room usage, overdose deaths, and prescribing patterns; implement a year-round drug take-back program that collected nearly 4,000 pounds of drugs in 2 years; train more than 100 law enforcement officers in the Substance Abuse and Mental Health Services Administration’s (SAMHSA) Creating Safe Scenes program; pilot a drug court through which more than 1,000 individuals received behavioral health therapy sessions, 102 individuals received in-patient treatment, and 45 individuals received outpatient treatment; and open a recovery home for individuals with SUD.