Prisma Health–Upstate focused on Oconee County, South Carolina, which is in the far northwest corner of the state with a population of 79,546 and the second-highest overdose death rate in the state. Prisma Health–Upstate implemented an evidence-based prevention program for 450 middle school students in the Oconee County School District and purchased 696 ready-to-use Narcan kits for distribution to schools and to individuals who are exiting law enforcement custody and are at high risk of an accidental overdose. RROE funds were also used to expand Oconee County’s existing Peer Support Specialist Program, including developing a partnership with the Oconee County Department of Probation and Parole and the Oconee County Drug Court that assisted 31 individuals. The peer support specialist also started several recovery meetings that were not previously offered, and the high amount of engagement with these meetings prompted a participating organization to open a physical location in Oconee County for meetings during and after the RROE grant period.